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Thyroid Function During Weight Loss A study published in Thyroid examined thyroid hormone changes during intentional weight loss and found that TSH and free T3 typically decrease modestly with caloric restriction and fat loss, independent of the weight loss method used
32,33 However, given the lack of comprehensive reviews in the existing literature on the pharmacokinetics and drug-drug interactions (DDIs) of GLP-1 RAs and a dual GLP-1/GIP RA, we produced this review to consolidate current knowledge and provide a thorough analysis of key considerations in clinical practice