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Metformin also comes with gastrointestinal side effects that make compliance difficult, and it does not directly address the appetite dysregulation that accompanies insulin resistance
Abstract In healthy individuals, the incretin hormone glucagon-like peptide 1 (GLP1) potentiates insulin release and suppresses glucagon secretion in response to the ingestion of nutrients
10.1016/j.pharmthera.2016.11.008 30 FinnerupN
However, to ensure maximum efficacy, we strongly advise refrigerating the vial as soon as you have the opportunity, and using an insulated bag and cold packs to help keep the medicine within the correct temperature range when refrigeration isnt available
Within the GLP-1RA group, discontinuing treatment for even 0.5 years was associated with a higher MACE risk compared to continued use
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