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Camilo Lyon, Chief Investment Officer [email protected] Media Contact: Curaleaf Holdings, Inc

As smoking tends to aggregate between spouses (smokers are more likely to marry smokers), misclassification of active smoking would tend to be differential on the basis of spousal smoking (the exposure under investigation)

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The study did not show any significant increase in neuropsychiatric adverse events attributable to varenicline or bupropion relative to nicotine patch or placebo