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The additional hydrogen donor and modified torsion angle strengthen base stacking and increase local thermal stability ( In summary, these RNA modificationsmethyl groups or isomerized basesuniquely reshape hydrogen bonding, base stacking, and charge, thereby directing RNA structure and interactions

292 The activation of STAT3 and STAT6 is also crucial for energy metabolism and microglial polarization, which are essential for maintaining cellular homeostasis and function

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These characteristics included greater reduction of hemoglobin A1c with treatment, longer duration of diabetes diagnosis and older subject age