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Studies Linking Ozempic/GLP-1 to NAION Several recent studies have found a potential link between semaglutide (the active ingredient in Ozempic, Wegovy and Rybelsus) and non-arteritic anterior ischemic optic neuropathy (NAION), including: NAION Signs & Symptoms NAION signs and symptoms can potentially include: Sudden vision loss in one eye Painless loss of vision Monocular vision loss Visual field defects Dark or shadowy areas in vision Altitudinal field defect Loss of vision in lower half of visual field Loss of vision in upper half visual field Blind spot in center of field of vision (central scotoma) Loss of vision in the outer parts of the visual field Peripheral vision loss Pale optic nerve head Pallor of the optic disc Optic disc edema (optic disc swelling) Optic nerve swollen Optic atrophy Optic nerve fibers degenerate Decreased visual acuity Reduction sharpness of vision Blood vessel abnormalities Peripapillary hemorrhage (bleeding) Optic disc hemorrhage Decreased color vision Absence of inflammation of the eye Afferent pupillary defect (APD) / Marcus Gunn Pupil Other NAION symptoms or signs Procedures and tests used by ophthalmologists (or neuro-ophthalmologists) to diagnose NAION can include a comprehensive eye exam (including visual acuity, color vision testing, pupil examination for an afferent pupillary defect, and dilated funduscopic examination to view the optic nerve), visual field testing, optical coherence tomography (OCT) of the optic nerve head and retinal nerve fiber layer, fluorescein angiography to assess optic nerve blood flow and blood tests to rule out other conditions