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Research shows these medications reduce the activation of the NLRP3 inflammasome in brain microglia, suppress pro-inflammatory cytokines including TNF-alpha, IL-1 beta, and IL-6 in the hippocampus and spinal cord, inhibit microglial activation in pain-processing centers, and reduce oxidative stress that contributes to nerve damage

[6] With Foundayo, Wegovy, and Zepbound all readily available in 2026, the prior shortage rationale for compounding has largely disappeared

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Vomiting rates were significantly lower compared to GLP-1 based treatments like Semaglutide and Liraglutide