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This finding aligns with previous studies, suggesting that short-acting agents may more readily cross the blood-brain barrier, thereby activating central GLP-1 receptors and exacerbating symptoms such as nausea and anorexia ( , dosed twice daily), which likely contributes to its higher vomiting risk due to frequent dosing and greater fluctuations in plasma concentrations

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And this stability allows the drug to go into the brain, where it squelches appetite and cravings directly, says Sandoval

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