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In vitro experiments have shown that tobacco smoke extract activates the MAPK/AP-1 signaling pathway and promotes aberrant proliferation of urothelial cells 23 , while nicotine contributes to tumor progression and chemoresistance through activation of the PI3K/AKT/mTOR signaling axis 24
Elliott, Stuart
doi:10.1016/s0306-4603(00)00151-9
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We pursue a safer cigarette, it would put us at extreme exposure with every other product." (On 60 Minutes, B&W said this was false.) Wigand made no secret of his lack of respect for Sandefur: "I wouldn't consider them all intellectual titans
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