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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

Many patients on PlexusDx compounded semaglutide inject weekly on the same day, making travel planning predictable and manageable

Neurological symptoms such as paraesthesia, balance problems, or cognitive difficulties typically take 36 months to improve and may continue improving for up to 1218 months

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