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Before opening a container stored in cold conditions, allow it to equilibrate to room temperature first to reduce moisture uptake from the surrounding atmosphere
Variations in dosage and formulation may occur, and side effects like nausea or gastrointestinal discomfort are possible
By contrast, linagliptin and alogliptin bind within the enzyme's catalytically active pocket through interactions with both the S 1 /S 2 and S 1 '/S 2 ' binding sites, which are formed by a combination of aromatic amino acids, including Phe357, Tyr547, Tyr631, Tyr666, Trp629, and His740
Sci Transl Med (2019) 11(478):eaau5758
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