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Antivir Chem Chemother (2004) 15:8391.10.1177/095632020401500204 45 SgarbantiRNencioniLAmatoreDColuccioPFraternaleASalePet alRedox regulation of the influenza hemagglutinin maturation process: a new cell-mediated strategy for anti-influenza therapy

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View Study [5]"Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris" Lu Z, Liu N, et al., 2023 Finding: Purified LR3 IGF-1 displayed excellent bioactivity for cell proliferation comparable to standard IGF-1, confirming that the molecular modifications preserve its biological function while extending its active lifespan

This biological and clinical variability reduces statistical power, introduces confounding variables, and may obscure the detection of true neuroprotective effects in trials [577, 578]