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To mitigate the inevitable issue of multicollinearity and potential effect modification among age at initiation, baseline age, and total pack-years, we based our analyses on a large population-wide cohort that allowed stratified analyses according to total pack-years of smoking exposure

An oral care routine for smokers should include: Brushing your teeth at least twice a day : Use fluoride toothpaste with a soft bristle toothbrush and floss to strengthen enamel and combat smoking teeth stains

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Its not known whether similar issues have occurred since then