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Therefore, we designed a multicenter, 12-week, randomized, placebo-controlled, double-blind study to compare the effectiveness of personalized doses of the nicotine patch (maximum of 84 mg/day) to standard 21 mg patch treatment in treatment-seeking adult smokers

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I dont know, thats what it says on Wikipedia

Common symptoms of bladder cancer may include: Frequent urination Pain or burning during urination Flank pain (discomfort in the sides of the lower back) A sudden, urgent need to urinate Blood in the urine, which may appear pink, red, or cola-colored Risk Factors for Bladder Cancer Smoking is one of the most dangerous contributors to bladder cancer