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Hornikx et al

Nicotine leaves the body in a few hours, but cotinine has a longer half-life, and is usually present for up to a week

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Pulmonary cells such as lung epithelial cells or alveolar macrophages could have different responses to CSE in terms of cellular NLRP3 protein levels, while monocytes or monocyte-derived macrophages have decreased NLRP3 protein levels upon exposure to CS, leading to immunosuppression [171]

Although the benefits of NRTs are well documented in peer-reviewed journals, achieving optimal results is a challenge