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However, unlike cancer, which is defined by uncontrolled cellular proliferation, NDDs primarily target specific neuronal populations and their niches, leading to irreversible neuronal loss and functional decline

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114,137 Its function in ST may be analogous to the function of menthol in cigarettes documented by Kreslake and Yerger, 115 showing industry-funded scientists found that stimulation of nociceptors in the trigeminal nerve could increase perceived sensory impact and act as enhancement or potential substitute for nicotine in cigarette smoking or produce anaesthetic effects to mask harsh tobacco flavour

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