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General best-practice guidance consistent with NHS and professional body recommendations supports regular resistance exercise and adequate dietary protein intake to help preserve muscle tissue during weight management

Jardine MJ, Mahaffey KW, Neal B et al (2017) The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) study rationale, design, and baseline characteristics

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The exact timing is completely personalit all depends on your bodys unique response, any underlying health issues, and how quickly you use and store Vitamin B12