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In contrast, solution from nicotine-free vape liquids (strawberry poptart and apple watermelon flavors) was shown to inhibit the activity of CYP2A6 (163).Together, these findings demonstrate both CYP isoform-specific and direction-specific effects following exposure to different electronic cigarette solutions

Exposure to Harmful Chemicals: While vaping eliminates many of the toxins produced by burning tobacco, e-liquids can contain potentially harmful chemicals, some of which are not well-researched

14 Figure 1 Daily smoking prevalence 1999-2019 among all and Mori and Pacific Year 10 students aged 14 to 15 years (ASH Snapshot Survey) For older age groups, smoking prevalence has decreased steadily, particularly since 2011/12 (see figure 2)

In the past 2 years, there have been significant efforts to improve education of physicians, which has likely contributed to the uptick in participation (57)