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HIV infection has been associated with dysbiosis of oral microbiome, with increased levels of pathogenic bacteria and fungi [74, 75], HIV-infected smokers showed rich abundance of specific bacterial taxa compared to infected non-smokers, including Granulicatella , Lactobacillus , Veillonella , Enhydrobacter , Streptococcaceae and Comamonadaceae , moreover, abundance of the fungal genus Candida was also increased in HIV-infected smokers [76]