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Epigenetics in human disease and prospects for epigenetic therapy

The cellular studies using CHO cells indicated that the pre-treatment of DSePA significantly upregulated the mRNA expressions of seleno-GPxs ( GPx1 , GPx2 , GPx3 , and GPx4 ), increased total GPx activity, and concurrently improved the viability of irradiated cells with a dose modification factor of 1.53 [85]

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in this regard, we analysed the proliferative and viability rate via the Alamar Blue test, lactate dehydrogenase (LDH) Activity as well as DNA fragmentation in apoptotic cells, which showed us that SHBG increased the proliferative potential of EqASC EMS , and protect DNA against its fragmentation

Zhang H, Xiao Y, Zhu Z, Li B, Greene MI