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Total cellular ROS and mitochondrial ROS were quantified using DCFDA and MitoSOX, respectively

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Presently, Pepinemab has entered clinical development for patients with solid tumors (NCT01313065, NCT03268057) and neurodegenerative diseases, including early Huntingtons disease and Alzheimers disease (NCT02481674, NCT04381468), demonstrating a favorable safety profile 78,79,80,81

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