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128 These findings demonstrate that glucagon activity regulates the proportion of the different endocrine cell types in islets, the number of islets in the pancreas, and the development of the mature alpha-cell phenotype

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Furthermore, TMAO levels have been reported to correlate with atherosclerotic plaque dimension and risk for cardiovascular events, such as myocardial infarction, stroke, and death over 3 years [67]

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