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Wu X, Jin S, Yang Y, Lu X, Dai X, Xu Z, et al

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Considering that P1 in rats corresponds to approximately 23 weeks gestation in humans, and P8 around delivery (101), these findings suggest that mid-gestational exposure to VPA produces excitatory-dominant E/I imbalance by blocking the excitatory-to-inhibitory shift of GABAergic signaling or reducing VGAT expression and decreasing GABA synthesis in the postnatal brain

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tested co-administration in rodent muscle/nerve injury models, showing stronger analgesic effects than either compound alone ( Journal of Basic and Clinical Physiology and Pharmacology, 26(5):517-523, 2015