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Perioperative management : According to 2024 multi-society guidance, most patients can continue GLP-1 receptor agonists perioperatively, though individualized risk assessment is recommended, particularly for major gastrointestinal surgery or procedures with high aspiration risk

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This process removes water under vacuum at very low temperatures, transforming the peptide into a stable, solid state that allows for shipping and storage without it breaking down

There were two further phase IIa studies evaluating cotadutide with the first one showing that it reduced glucose levels in those with obesity and T2DM with the mechanism being greater insulin secretion and delayed gastric emptying [46]

Research into these combination approaches should be prioritized to enhance the therapeutic potential of ferroptosis-targeting drugs