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The dosages that researchers used in these studies ranged from 336 mg daily of cinnamon extract to 1500 mg daily in capsule form over 6 to 24 weeks, indicating the need for further investigations to determine the right dosing and duration of therapy

A rapid burst of plasma acrolein as an active metabolite of AA, as well as plasma endogenous reactive aldehydes malondialdehyde (MDA) and formaldehyde, was observed at 10 min after exposure to 75 mg/kg of AA in the Aldh2*2 KI homozygous mice, which was not evident in the wild-type mice

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There was no control group, no placebo arm, no blinding

These symptoms typically occur during treatment initiation or dose escalation and often improve over several weeks as the body adapts