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The lower nausea and vomiting rates with tirzepatide compared to CagriSema suggest it may be easier to tolerate, particularly during the titration phase

Common Vial Sizes and Concentrations Vial size 50 mg BAC water 2.0 mL Concentration 25.0 mg/mL 1 mg draw (U-100) 0.04 mL = 4 units Vial size 50 mg BAC water 2.5 mL Concentration 20.0 mg/mL 1 mg draw (U-100) 0.05 mL = 5 units Vial size 100 mg BAC water 3.0 mL Concentration 33.3 mg/mL 1 mg draw (U-100) 0.03 mL = 3 units Vial size 100 mg BAC water 5.0 mL Concentration 20.0 mg/mL 1 mg draw (U-100) 0.05 mL = 5 units Pick a reconstitution volume that produces a draw you can read cleanly on a U-100 syringe

We acknowledge that we had stated in last year's final rule that we would provide public education and instruction through MLN and anticipate that we will do so

Unreconstituted powder lasts much longer than reconstituted solution

The retheorization will take three steps