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Similarly, PEGylated IL-1Ra chimeric protein nanoparticles prolong half-life, enabling sustained blockade of the IL-1 pathway and inhibition of MSU crystal-induced inflammation

The proposed mechanism involves these bacteria producing metabolitessuch as short-chain fatty acids (SCFAs)that interact with enteroendocrine cells in the intestinal lining, potentially stimulating endogenous GLP-1 release

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Those on Wegovy lost an average of 41 lb, and those on Zepbound dropped an average of 55 lb before reaching a plateau