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It has been investigated in research settings for its involvement in energy homeostasis, insulin sensitivity pathways, and stress-response signaling mechanisms

The classification of a medicine is based on the level of health professional input needed to diagnose and manage the conditions for which the product is used

However there were notable outliers such as endomorphin-2, which is a relatively weak G protein activator but very effectively stimulates the phosphorylation of Ser375

Bohn et al., 1999, 2002), but we prefer to use the term tolerance for such prolonged exposure, qualified as acute (several hours, Cox et al., 1968) or long-term (days) to avoid confounding the mechanisms of rapid desensitization of MOR with potentially different mechanisms of tolerance

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