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Frederick Sanger went on to discover the exact amino acid sequence, earning the first of his 2 Nobel Prizes

Using a novel highly sensitive mass spectrometry approach based on Surface-Activated Chemical Ionization (SACI) with an Electrospray Ionization (ESI) source and bioinformatics analyses (SANIST platform) for biomarker discovery, we had found that 3 molecules from the carnitine family were significantly decreased in serum sample from PCa patients, as compared to controls [16]

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J Biol Chem 277: 310317 Zapun A, Darby NJ, Tessier DC, Michalak M, Bergeron JJ, Thomas DY (1998) Enhanced catalysis of ribonuclease B folding by the interaction of calnexin or calreticulin with ERp57