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Three patients were given 5 mg at bedtime, while one was started on 5 mg three times a day (TID) and gradually raised to 10 mg TID due to worsening symptoms (Carr et al

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Cigarette smoke, carbon monoxide and nicotine induce some of the biochemical, anatomical and pathophysiological changes seen in CHD, but prospective epidemiological studies document that cessation of cigarette smoking results in reduced mortality from CHD. Editorial The Grave Facts About Smoking, Medical Journal of Australia, July 26, 1975, Pages 120-121 What Did We Do About It