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Nicotine can stimulate the neuronal release of dopamine and endogenous opioid peptides and activate the reward center of the brain

Department of Health and Human Services, Centers for Disease Control and Prevention, Coordinating Center for Health Promotion, National Center for Chronic Disease prevention and Health Promotion, Office on Smoking and Health, 2006

Abstract Two primary ovarian hormones that fluctuate across the female menstrual cycleestradiol and progesteronehave been independently linked in separate literatures to nicotine reinforcement and anxiety psychopathology

doi:10.3390/ijerph10104790

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