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M1 microglia exacerbate seizures and depressive symptoms by releasing pro-inflammatory cytokines, including C-X-C motif chemokine ligand 8 (CXCL8), IL-1, IL-6, and TNF-, which promote neuroinflammation and neuronal injury

In women with PCOS who have vitamin D deficiencies, co-supplementation of calcium and vitamin D has demonstrated improvements in -cell function, TAC, high-sensitivity C-reactive protein (hs-CRP), and glutathione (GSH) levels [142]