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Some individuals have documented sensitivity to benzyl alcohol

In adults with obesity but without diabetes, REDEFINE-1 Phase III showed a mean body weight loss of 22.7% with CagriSema compared to 15.7% seen in the semaglutide alone group, demonstrating 44% greater weight loss efficacy

The 5HT 2C receptors are suspected in control of food intake as mice lacking this gene become obese from increased food intake and are also subject to fatal seizures