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All the animal procedures were approved by the Institutional Animal Care and Use Committee (IACUC) and complied with all state, federal, and NIH regulations

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20 Acknowledgements This research was supported by the National Cancer Institute of the United States through The University of Illinois at Chicago Cancer Center, Cancer Education and Career Development Program (R25-CA57699) and the Roswell Park Transdisciplinary Tobacco Use Research Center (RO1 CA100362 and P5OCA111236) as well as by the Canadian Institutes of Health Research (57897 and 79551)