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Conclusion In summary, the literature suggests that the critical problem for long-term retrospective studies is not that every retrospective report is invalid, but that denials of infant ETS are unreliable in a nontrivial subset of cases

Future studies using microdissection of the lung tissue or singe-cell sequencing, as well as (co-)cultures of several cell populations may contribute to the understanding of the regulation of mitochondrial turnover and metabolism and the involvement of specific cell types in the context of COPD

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