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35,43 Meta-analyses evaluating percutaneously placed interspinous spacer devices found that although there may be some benefit in patients without spondylolisthesis who have extension-based neurogenic claudication, there are high rates of complications and reoperation

the mitigation column below is deliberately conservative, and the recurring theme is that technique and consistency solve more problems than dose changes

A spinoff company, Athira Pharma (formalized as M3 Biotechnology before rebranding), was founded in 2011 by PhD student Leen Kawas to commercialize dihexa and a related molecule, ATH-1017 (fosgonimeton)