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Antioxidants are adjunctive to medical therapy Oral antioxidants include vitamin B, C, polypodium, glutathione & melatonin Topical antioxidants include vitamin B, C, E, & ferulic acid Oral antioxidants are easier to use for most patients Topical antioxidants can be considered in some patients Skin irritation is the most common side effect of topical antioxidants, esp

The traditional PNT method can reduce mtDNA residue in mice [137]

When protein misfolding occurs, there is another way of cell protection called the integrated stress response (ISR)

The reaction was then stopped in an ice bath