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IBD is associated with the dysregulation of the symbiotic relationship between the commensal ecosystem and the mucosal immune system ( Crohns disease (CD) and ulcerative colitis (UC) are the two major phenotypes of IBD, and they differ meaningfully in their biology, barrier injury patterns, and epithelial restitution mechanisms

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Upon activation, cytokine and chemokine production by activated KCs is involved in the pathogenesis of liver damage