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With this kind of clinical trial data determining the general safety profile of e-cigarettes, regulatory guidelines defining their proper use and public perception can be better formulated. Enough evidence of harm to implement protective measures Already several comprehensive scientific reviews have been conducted about the health effects of vaping on behaviour of major health authorities like the World Health Organization (2015), Public Health England (2015, 2018), the National Academies of Science, Engineering and Medicine (2018), Public Health Ontario (2018) and others