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There was not a significant difference in serious adverse events among patients on brodalumab or placebo

However, given the rarity of the occurrence of SSIBs, the size of the RCT, and the limitations of the retrospective studies, higher-quality and larger prospective trials are needed to determine the credibility of the current conclusions

More recently, two dual-acting GLP-1/GIP agonists have been approved, Mounjaro (tirzepatide) for type 2 diabetes and Zepbound (tirzepatide) for chronic weight management