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Metabolism is the energy that's needed for our body to function from breathing, to running, to exercise, everything, says Marcio Griebeler, MD, an endocrinologist and obesity specialist with the Cleveland Clinic's endocrinology and metabolism institute in Avon, Ohio

This framework also provides a biologic link to epidemiologic associations between smoking and myeloproliferative neoplasms, in which clonal expansion may be favored in a stressed and disordered marrow environment

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hypermobility ranging from mild to serious