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Quick Answer: Half-life determines how often a drug must be dosed Half-life is determined by elimination processes

You still need movement so you lose fat and not muscle

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Animal reproductive studies showed no teratogenic effects, but human pregnancy data remains limited

Source: The New England Journal of Medicine Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff et al., 2022) Figure 1A Average Weight Loss After 72 Weeks At 72 weeks, participants taking tirzepatide once weekly lost significantly more weight than those on placebo: 5 mg dose: 15.0% average body weight reduction 10 mg dose: 19.5% reduction 15 mg dose: 20.9% reduction Placebo: 3.1% reduction All tirzepatide doses showed much greater weight loss compared to placebo