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Nicotine exposure gives rise to differential gene expression of endothelial cells, growth of atherosclerotic plaques, and angiogenesis [111, 112]

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This is because CO displaces O 2 from hemoglobin forming carboxyhemoglobin (CO affinity for hemoglobin is 200 times that of O 2 ) and shifting the oxygen dissociation curve to the left, thereby causing hypoxia and impairment of cellular respiration [76]

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It still has that grip in popular culture." The thing most people don't realize as they worry over the dangers of stress, Petticrew says, is that much of this foundational scientific research on stress was funded and guided by a very particular sponsor