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One targets a single process in a single tissue type

As the deficiency is managed, the frequency can be reduced to weekly and then monthly for upkeep

Abbreviations ACS: acute coronary syndrome CV: cardiovascular GLP-1RA: glucagon-like peptide-1 receptor agonist DPP-4: dipeptidyl peptidase-4 HF: heart failure MACE: major adverse CV event SGLT2: sodium-glucose cotransporter 2 T2D: type 2 diabetes References Zinman B, Wanner C, Lachin JM, Fitchett D, Bluhmki E, Hantel S, Mattheus M, Devins T, Johansen OE, Woerle HJ, et al

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where S is the substrate (GSH), v is the reaction rate, k1 is the apparent first-order rate constant k1 was calculated based on the slope of fitted v -[ S ] curve