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Although vancomycin has been linked to hepatic injury in case reports, evidence for its role in causing severe multisystem toxicity remains limited ( Tislelizumab, a PD-1 inhibitor, carries a recognized risk of immune-related hepatitis (irH) ( The patient reported chronic heavy alcohol intake (~200 g/day), which is recognized as a susceptibility factor in RUCAM and was incorporated into the risk-factor domain together with age 55 years (maximum contribution)

The signaling pathway involving STAT3/Nrf2/GPX4 is integral to the resistance observed in osteosarcoma cells and may serve as a promising therapeutic target to improve the effectiveness of cisplatin against bone tumors ( Figure 6 ) (191)

Wishing you all great health, Warm regards, Rajsree Nambudripad, MD

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