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Mucocutaneous features of Ehlers-Danlos syndrome Classic Ehlers-Danlos syndrome (MIM 130000) has the additional cutaneous features: Soft velvety skin Normal skin recoil after stretching Hyperlinear loose skin on the palms and soles Lax skin around the eyes and face forming folds in later life Lack of stretch marks in pregnancy Wounds heal slowly to leave wide 'cigarette-paper' scars Molluscoid pseudotumours - spongy blue-grey lumps over pressure points and scars Calcified spheroids - small, firm, subcutaneous nodules on forearms and shins Pigmentation following repeated bruising of easily traumatised sites Piezogenic pedal papules

A decent mac is stylish yet very versatile and combined with a flat cap normally means I dont need a brolly

The big three cities of Cincinnati, Columbus and Cleveland are spread out geographically, which will allow us to examine regional trends during the launch, to better shape our expansion strategies

Of particular interest was whether they began to smoke at a young age before puberty or during adolescence

INTRODUCTION Tobacco consumption is a major contributing and risk factor and the 6th leading cause of death globally 1