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4 Thus, defects in SLC25A39 induce severe disturbances in the mitochondrial GSH-import machinery contributing to neuronal degeneration

Importantly, gastrointestinal adverse events (nausea, vomiting, diarrhoea) occurred in 3045% of participants during dose escalation but typically resolved within 48 weeks

While foods like spinach, avocados, and asparagus contain glutathione, the amounts are relatively small and much of it is lost during cooking or digestion

Many chronic health conditions can be associated with insufficient glutathione, including autoimmune disorders, fibromyalgia, and skin disorders

Therefore, exploring the role of ferroptosis in the occurrence and development of PCOS can provide more ideas for mechanistic research on PCOS and more potential targets for PCOS treatment