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Moreover, the competitive selective nACh receptor antagonist hexamethonium inhibited sensory nerve stimulation in response to TS, but had no effect on other tussive stimuli, indicating a role for nicotine in the smoke-induced irritant response in dogs (Lee et al., 1983, 1985, 1986, 1989

The follow-up-time is long (18.48 years), and the sample is very large (N = 8718 in this study)

The government's move to regulate this is welcomed