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A prospective randomized controlled study evaluating the potential preventive effect of L-carnosine on acute oxaliplatin neurotoxicity in patients with colorectal cancer enrolled 65 patients and showed that the levels or activities of NFB (27%) and TNF- (36.6%) were significantly decreased in the group receiving the FOLFOX-6 regimen (oxaliplatin, 5FU, and leucovorin) with daily oral L-carnosine (500 mg), while L-carnosine as a supplement for patients with CIPN alleviated neuropathic symptoms by decreasing oxidative stress (Nrf-2 and NF-B pathways) and apoptosis (caspase-3 activity) [144]

doi: 10.3389/fcimb.2017.00381 84 AltemaniFBarrettHLGomez-ArangoLJoshPMcintyreHDCallawayLKet al

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372 doi: (Published 13 January 2021)Cite this as: BMJ 2021;372:m4573 Abstract Objective To evaluate sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists in patients with type 2 diabetes at varying cardiovascular and renal risk

Thats a long half-life, it can exert its pharmacological actions in the hosts body for the same duration