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Note additionally that the three methionine residues in the sequence, two of them in the N-terminal extension, make dilute standing solution vulnerable to oxidation, and that freeze-thaw cycling promotes aggregation in disulfide-bonded proteins more readily than in short peptides
C.et al (2021)
Ferrous sulfate is one of the most common forms of iron recommended by healthcare providers
In order to prevent oxidative stress due to increased intracellular iron and subsequent cell death by ferroptosis, OLs can export iron via FPN that acts in concert with ferroxidases, as evidenced by increased oxidative stress in OLs deficient for hephaestin (54)
doi: 10.1038/nature24661 209 HassunaNARabieEMMahdWKMRefaieMMMYousefRKMAbdelraheemWM
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