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It is also recognized that smoke exposure leads to the activation of the Nod-like receptor protein 3 (NLRP3) inflammasome [63], with consequent local generation of active interleukin 1 (IL-1), a process that induces inflammation and thereby can lead to both chronic fibrosis and cancer in mice [64]

2) reasons for initiation and changes in reasons over the period

Text originating from posts that were not accessible were still included in the thematic analysis to ensure the comprehensive nature of the original data was maintained

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For instance, implementing strategies to improve access to PA facilities (e.g., providing free transportation) and modifying public and private spaces (such as workplaces for people who choose to work in later life) to promote PA and reduce sedentary behavior are necessary to promote an active lifestyle [97,117]